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Hypocretin deficiency is a known cause of narcolepsy; therefore, it is likely that future treatment will address correction of the deficit. According to one study, one dose of hypocretin-1 administered intranasally to 14 patients reduced REM sleep duration, reduced wake-REM sleep transition during the day, and improved attention in type 1 narcoleptics. 31 Larger-scale studies must be conducted in order to confirm efficacy. Another possible option to correct the hypocretin deficiency resides with the development of a nonpeptide hypocretin receptor agonist. However, such a chemical compound has not yet been successfully developed. 32 Other options currently undergoing studies include hypocretin neuronal cell transplantation and gene therapy. The latter involves the delivery of a transgene via a viral vector that allows expression of hypocretin in animals and humans lacking the anatomical means to produce hypocretin. The recombinant adeno-associated virus has been used to deliver the hypocretin gene in mice, which led to increased hypocretin-1 levels and decreased cataplexy. 33,34. Get medical help right away if you have any very serious side effects, including: chest pain, seizures. What are the ingredients in ADDERALL XR? Different pharmacokinetic parameters depending on dose administered. Time to peak 2 6 hours; T 1/2 =19 37 hours plasma protein binding (97%); found in breast milk.; extensive hepatic metabolism; desmethylclomipramine (major active metabolite). Elimination: feces (24% 32%), urine (51% 60%); T 1/2 =32 hours (clomipramine), 69 hours (desmethylclomipramine). Reach out to 1(916) 407 2673. Results of a phase II study suggested that a stimulant drug approved to treat attention deficit-hyperactivity disorder (ADHD) may improve cognitive function in adults with major depression, its manufacturer said. Q: I've been refilling the same generic drug prescription at my pharmacy for months without incident, but this month, I was given pills that are a different shape and color. The pharmacist says are the same medication. Isn't this confusing? Why does it happen? I wondered it it might help to call the
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